XALKORI® (crizotinib) For ALK+ or ROS1+ mNSCLC Treatment

Having NSCLC can be a confusing experience. That's why, as pioneers in the treatment of ALK+ or ROS1+ NSCLC that has spread to other parts of the body (metastatic), we're here to be a dedicated and knowledgeable partner throughout your treatment with XALKORI.

What to expect

Let’s learn about how to take XALKORI capsules, and its side effects.

Side effects Taking XALKORI

is here for you:

Financial assistance

We’ll help you find financial assistance options for your prescribed XALKORI, including a co-pay savings program for eligible, commercially insured patients. Limits, terms, and conditions apply.* We can also help identify resources if you have Medicare, another government insurance plan, or don’t have health insurance.

*Patients are not eligible to use this card if they are enrolled in a state or federally funded insurance program, including but not limited to Medicare, Medicaid, TRICARE, Veterans Affairs health care, a state prescription drug assistance program, or the Government Health Insurance Plan available in Puerto Rico. Patients may receive up to $25,000 per product in savings annually. The offer will be accepted only at participating pharmacies. This offer is not health insurance. No membership fees apply. Pfizer reserves the right to rescind, revoke, or amend this offer without notice. For any questions, please call 1-877-744-5675, visit PfizerOncologyTogether.com/terms or write: Pfizer Oncology Together Co-Pay Savings Program, 2250 Perimeter Park Drive, Suite 300, Morrisville, NC 27560.

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*Patients are not eligible to use this card if they are enrolled in a state or federally funded insurance program, including but not limited to Medicare, Medicaid, TRICARE, Veterans Affairs health care, a state prescription drug assistance program, or the Government Health Insurance Plan available in Puerto Rico. Patients may receive up to $9,450 per product in savings annually. The offer will be accepted only at participating pharmacies. This offer is not health insurance. No membership fees apply. Pfizer reserves the right to rescind, revoke, or amend this offer without notice. For full Terms and Conditions, please see PfizerOncologyTogether.com/terms. For any questions, please call 1-877-744-5675, visit PfizerOncologyTogether.com/terms, or write: Pfizer Oncology Together Co-Pay Savings Program, 2250 Perimeter Park Drive, Suite 300, Morrisville, NC 27560.

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Important Safety Information & Indications

Indications

XALKORI is a prescription medicine used to treat adults with non-small cell lung cancer (NSCLC) that has spread to other parts of the body and is caused by a defect in either a gene called ALK (anaplastic lymphoma kinase) or a gene called ROS1. It is not known if XALKORI is safe and effective in children with NSCLC.

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Important Safety Information

XALKORI^® (crizotinib) may cause serious side effects, some of which may include:

Liver problems — XALKORI may cause life-threatening liver injury that may lead to death. Your healthcare provider should do blood tests to check your liver every 2 weeks during the first 2 months of treatment with XALKORI, then one time a month. Tell your healthcare provider right away if you get any of the following new or worsening symptoms:

yellowing of your skin or the white part of your eyes
severe tiredness
dark or brown (tea color) urine
nausea or vomiting

decreased appetite
pain on the right side of your stomach
bleed or bruise more easily than normal
itching

Lung problems (pneumonitis) — XALKORI may cause life-threatening lung problems that may lead to death. Symptoms may be similar to those symptoms from lung cancer. Tell your healthcare provider right away if you have any new or worsening symptoms, including:

trouble breathing or shortness of breath
cough with or without mucous
fever

Heart problems — XALKORI may cause very slow, very fast, or abnormal heartbeats. Your healthcare provider may check your pulse rate and blood pressure during treatment with XALKORI. Tell your healthcare provider right away if you feel dizzy or faint or have abnormal heartbeats. Tell your healthcare provider if you take any heart or blood pressure medicines.

Severe vision problems — Vision problems are common with XALKORI. These problems usually happen within 1 week of starting treatment with XALKORI. Vision problems with XALKORI can be severe and may cause partial or complete loss of vision in one or both eyes. Your healthcare provider may hold or stop XALKORI and refer you to an eye specialist if you develop any vision problems during treatment with XALKORI. Tell your healthcare provider right away if you have any new vision problems, loss of vision or any change in vision, including:

double vision
seeing flashes of light
blurry vision

light hurting your eyes
new or increased floaters

Before you take XALKORI, tell your healthcare provider about all of your medical conditions including if you:

have liver or kidney problems
have lung problems
have heart problems, including a condition called long QT syndrome
have vision or eye problems

are pregnant, or plan to become pregnant. XALKORI can harm your unborn baby
- Females who are able to become pregnant should use effective birth control during treatment with XALKORI and for 45 days after the last dose of XALKORI.
- Your healthcare provider will check to see if you are pregnant before starting treatment with XALKORI
- Males who have female partners who can become pregnant should use condoms during treatment with XALKORI and for 90 days after the last dose of XALKORI.
- Talk to your healthcare provider about birth control methods that may be right for you.
- If you or your partner becomes pregnant, tell your healthcare provider right away.
are breastfeeding or plan to breastfeed. It is not known if XALKORI passes into your breast milk. Do not breastfeed during treatment with XALKORI and for 45 days after the last dose. Talk to your healthcare provider about the best way to feed your baby during this time

Tell your healthcare provider about the medicines you take, including prescription, and over-the-counter medicines, vitamins, and herbal supplements. XALKORI can affect the way other medicines work, and other medicines can affect how XALKORI works.

Do not drink grapefruit juice, eat grapefruit or take supplements containing grapefruit extract during treatment with XALKORI. It may increase the amount of XALKORI in your blood to a harmful level.

The most common side effects of XALKORI in adults with NSCLC include:

vision problems
nausea, diarrhea, or vomiting
swelling of your hands, feet, face, or eyes
constipation

increased liver function blood test results
tiredness
decreased appetite
upper respiratory infection
dizziness
feeling of numbness or tingling in your arms or legs

XALKORI can cause changes in vision, dizziness, and tiredness. Do not drive or operate machinery if you have any of these symptoms.

Avoid spending prolonged time in sunlight. XALKORI can make your skin sensitive to the sun (photosensitivity), and you may burn more easily. You should use sunscreen and wear protective clothing that covers your skin to help protect against sunburn if you have to be in the sunlight during treatment with XALKORI.

XALKORI may cause fertility problems in females and males, which may affect the ability to have children.

These are not all of the possible side effects of XALKORI.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Please see Full Prescribing Information and Medication Guide.

Indications

XALKORI is a prescription medicine used to treat people with non-small cell lung cancer (NSCLC) that has spread to other parts of the body and is caused by a defect in either a gene called ALK (anaplastic lymphoma kinase) or a gene called ROS1. It is not known if XALKORI is safe and effective in children.